Auriane destrument elucidating the role of mkk4 in neuronal apoptosis

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auriane destrument elucidating the role of mkk4 in neuronal apoptosis-65auriane destrument elucidating the role of mkk4 in neuronal apoptosis-47auriane destrument elucidating the role of mkk4 in neuronal apoptosis-31

This review will discuss how these unexpected findings have increased our understanding of the role of JNK signaling in cancer and have provided a source of new working hypotheses.

Its activity is increased upon phosphorylation by the MAPK kinases, MKK4 and MKK7.

Similar to the early embryonic death of mice caused by the targeted deletion of the die before birth.

The inability of MKK4 and MKK7 to compensate for each other's functions in vivo is consistent with their synergistic effect in mediating JNK activation.

However, the phenotypic analysis of the mutant mouse embryos indicates that MKK4 and MKK7 have specific roles that may be due to their selective regulation by extracellular stimuli and their distinct tissue distribution.

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